A space suit is a form of clothing used to protect the human body from the vaccume of space. Throughout the Space Odyssey film and book series, space suits are used quite often.
trivia
The blue spacesuit on the Discovery 1 the only one that was never used, in either 2001 and 2010 was later used in the Babylon 5 episodes #1.20, "Babylon Squared" and #3.17,
"War Without End: Part 2"